Cystic Neutrophilic Granulomatous Mastitis: Association With Gram-Positive Bacilli and Corynebacterium.
نویسندگان
چکیده
OBJECTIVES To determine whether cystic neutrophilic granulomatous mastitis (CNGM) can be associated with Gram-positive bacilli and Corynebacterium METHODS We reviewed our experience with 35 granulomatous mastitis patients over a 10-year period, including histologic pattern, Gram stain and other microbiologic data, clinical presentation, treatment and outcome. RESULTS Biopsies from 19 patients demonstrated CNGM, while 16 patients had other patterns of granulomatous mastitis. Gram-positive organisms were seen within microcystic spaces in 16/19 CNGM, but 0/16 non-CNGM patients (P = .000). Culture or molecular studies demonstrated Corynebacterium species in three, all CNGM. Patients with CNGM were more likely to be younger, of Hispanic ethnicity, and born outside of the United States. Granulomatous mastitis resolved after a protracted course with widely variable treatment (antibiotics, surgery, steroids). CONCLUSIONS Our data further support CNGM as an infectious disease; further study of Corynebacterium-directed therapy in CNGM is needed.
منابع مشابه
Anatomic Pathology / Cystic Neutrophilic Granulomatous Mastitis
Although granulomatous lobular mastitis is associated with gram-positive bacilli such as Corynebacterium, this association is not well known. We report 3 cases of mastitis caused by gram-positive bacilli. All 3 abscesses were suppurative with distinct enlarged cystic spaces in which rare gram-positive bacilli were identified. Two cases were also granulomatous. Cultures in all 3 cases were negat...
متن کاملCorynebacterium accolens isolated from breast abscess: possible association with granulomatous mastitis.
Corynebacterium accolens is rarely isolated as a human pathogen. We describe here a case of C. accolens isolated from a breast abscess in a patient previously diagnosed with granulomatous mastitis. The possible association of Corynebacterium accolens and granulomatous mastitis in this patient is discussed.
متن کاملGranulomatous Mastitis Breast Abscess: Possible Association with Isolated from Corynebacterium accolens
متن کامل
Relationship between Mastitis Agents and Somatic Cell Count in Foremilk Samples
The purpose of the study was to determine the microorganism species dependently on somatic cell count (SCC) in foremilk (inflammatory secretion) samples. Bacteriological examinations of 18 713 samples taken from clinically and subclinically (CMT positive) inflamed quarters were performed according to standard methods. Above 13% of the samples originated from quarters previously treated with ant...
متن کاملGranulomatous mastitis. A review of 5 cases.
A review of 67 cases diagnosed as granulomatous, tuberculous or fungal mastitis revealed 5 cases which were similar, clinically and histopathologically, to the new entity of granulomatous mastitis described by Kessler and Wolloch. The 5 patients were young women of childbearing age, 4 with breast lesions clinically simulating carcinoma of the breast. Histopathological examination showed granulo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- American journal of clinical pathology
دوره 145 5 شماره
صفحات -
تاریخ انتشار 2016